Protein Modification Reagents
Medchemexpress LLC NH2-PEG4-DOTA | 2090232-34-9 | 97.0% | 622.71 g/mol | C26H50N6O11 | 1mL
NH2-PEG4-DOTA is a bifunctional DOTA-type metal chelator NH2-PEG4-DOTA can be conjugated with Dextran for quantitative analysis in the presence of a highly luminescent complex NH2-PEG4-DOTA can also bind to radionuclides to prepare radionuclide drug conjugates (RDCs) RDCs have the ability to specifically target biomolecules and can be used in medical imaging or therapy
Medchemexpress LLC DBCO-PEG4-Val-Cit-PAB-PNP | 2226472-28-0 | 97.3% | 1079.16 | C55H66N8O15 | 50 MG
DBCO-PEG4-Val-Cit-PAB-PNP is a cleavable antibody-drug conjugate (ADC) linker for bioconjugation and click-chemistry applications. It combines a dibenzocyclooctyne (DBCO) moiety for copper-free SPAAC conjugation with a PEG4 spacer for solubility and flexibility, a Val-Cit protease-cleavable dipeptide linked to a PAB self-immolative spacer, and a PNP leaving group for amine-mediated payload attachment.
- Contains DBCO for copper-free strain-promoted azide-alkyne cycloaddition.
- Includes PEG4 spacer to improve solubility and reduce steric hindrance.
- Features Val-Cit dipeptide cleavable by cathepsin B for selective payload release.
- Incorporates a PAB self-immolative spacer to enable rapid payload liberation after cleavage.
- Provides a PNP leaving group for straightforward amine coupling of payloads.
- Suited for synthesis of ADCs and conjugation to azide-bearing molecules.
Medchemexpress LLC HY-112617A 100mg Medchemexpress, Thalidomide-O-amido-PEG2-C2-NH2 (TFA) CAS:1957235-75-4 Purity:>98%
Medchemexpress, HY-113143A 50mg Galactose 1-phosphate Potassium salt CAS:19046-60-7 Galactose 1-phosphate Potassium salt is is an intermediate in the galactose metabolism and nucleotide sugars. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
eMolecules Tos-PEG13-Tos | Broadpharm | 1456708-45-4 | MFCD28334513 | 855.020 | C38H62O17S2 | 98.000 | Cc1ccc(cc1)S(=O)(=O)OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOS(=O)(=O)c1ccc(C)cc1 | 1g | 268504942
Tos-PEG13-Tos | Broadpharm | 1456708-45-4 | MFCD28334513 | 855.020 | C38H62O17S2 | 98.000 | Cc1ccc(cc1)S(=O)(=O)OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOS(=O)(=O)c1ccc(C)cc1 | 1g | 268504942
Medchemexpress LLC Biotin-PEG2-azide | 1910803-72-3 | 97.0% | 250 MG
Biotin-PEG2-azide is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an Azide group that can participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules possessing Alkyne groups. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions when combined with molecules containing DBCO or BCN groups. These PROTACs leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins. It is intended for research use only.
- PEG-based PROTAC linker
- Utilized in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an Azide group
- Participates in copper-catalyzed azide-alkyne cycloaddition reactions
- Undergoes strain-promoted alkyne-azide cycloaddition reactions
- Useful in cancer research and targeted therapy
Medchemexpress LLC Aminooxy-amido-PEG4-propargyl | 2253965-03-4 | 97.0% | 304.34 | C13H24N2O6 | 100 MG
Aminooxy-amido-PEG4-propargyl is a PEG4 linker bearing an aminooxy group and a terminal propargyl (alkyne) functionality. It is used as a click-chemistry reagent for copper-catalyzed azide-alkyne cycloaddition and as a non-cleavable spacer in antibody-drug conjugate and bioconjugation chemistry.
- Molecular weight 304.34.
- Purity 97.0%.
- Chemical formula C13H24N2O6.
- CAS number 2253965-03-4.
- Available in 100 MG and other pack sizes.
- Suitable for CuAAC click chemistry and bioconjugation.
Medchemexpress LLC Fmoc-NH-PEG4-CH2COOH | 437655-95-3 | 99.1% | 473.52 | C25H31NO8 | 5 G
Fmoc-NH-PEG4-CH2COOH is an Fmoc-protected PEG4 linker bearing a terminal carboxylic acid. It is used as a cleavable ADC linker and as a PEG-based PROTAC linker for conjugation and linker synthesis. The compound has molecular formula C25H31NO8 and molecular weight 473.52 and is supplied at high purity for research use.
- Fmoc-protected amine compatible with solid-phase and solution-phase synthesis.
- Terminal carboxylic acid enables standard coupling reactions.
- Peg4 spacer increases solubility and provides linker flexibility.
- High purity suitable for research and conjugation chemistry.
- Available in multiple sizes, including a 5 g package.
Medchemexpress LLC Nhpi-PEG4-C2-NHS ester | 1415328-95-8 | 98.9% | 508.48 g/mol | C23H28N2O11 | 250 MG
NHPI-PEG4-C2-NHS ester is an NHPI-activated PEG4-based NHS ester linker used for bioconjugation and antibody-drug conjugate (ADC) synthesis. It is supplied as a solid for research use and is reported at approximately 98.9% purity.
- CAS number: 1415328-95-8.
- Molecular weight 508.48 g/mol.
- Chemical formula C23H28N2O11.
- Useful as an NHS ester for amine coupling and ADC linker synthesis.
- Available in multiple package sizes, including 250 MG.
- For research use only; not for clinical or human therapeutic use.
Cayman Chemical dPE-PEG 2000-DBCO 5mg
A metabolite of carbamazepine and oxcarbazepine has been found in wastewater effluent
Medchemexpress LLC (S,R,S)-AHPC-PEG4-NH2 | 2010159-57-4 | MFCD31657338 | 95.6% | 663.83 | C32H49N5O8S | 25 MG
(S,R,S)-AHPC-PEG4-NH2 is an E3 ligase ligand-linker conjugate that combines a VHL-targeting AHPC ligand with a four-unit PEG linker for use in PROTAC design and targeted protein degradation research. It is supplied as a solid powder for laboratory synthesis and biochemical studies.
- Designed for VHL-mediated targeted protein degradation applications.
- Contains a four-unit polyethylene glycol linker to provide flexibility and solubility.
- White to off-white solid powder form suitable for synthesis workflows.
- CAS number 2010159-57-4 for unambiguous identification.
- Molecular weight 663.83 g·mol-1 and formula C32H49N5O8S.
- Recommended storage: powder -20°C (3 years) or 4°C (2 years).
Medchemexpress LLC Biotin-PEG6-Mal | 1808990-66-0 | 99.0% | C31H51N5O11S | 50 MG
Biotin-PEG6-Mal is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs (Proteolysis Targeting Chimeras) consist of two different ligands connected by a linker; one ligand is for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Biotin-labeled
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- PROTACs selectively degrade target proteins by utilizing the ubiquitin-proteasome system
Medchemexpress LLC DMG-PEG-Mal | 99.3% | 2000 (Average) | 10 MG
DMG-PEG-Mal (MW 2000) is a maleimide-functionalized PEGylated lipid used to improve delivery efficiency and tissue specificity of poorly soluble drugs. It is commonly used in formulation research such as lipid nanoparticles and liposomes, where the maleimide group enables conjugation to thiol-containing ligands.
- Molecular weight 2000 (average).
- Maleimide-functionalized PEG backbone for thiol conjugation.
- High purity (about 99.3%).
- White to off-white solid appearance.
- Available in small research quantities including 10 mg.
- Powder storage: -20°C (stable for up to 3 years); in solvent: -80°C for 6 months or -20°C for 1 month.
- Intended for research use only; not for human use.